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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression

Fig. 7

MIR31HG suppressed HCC tumor growth and metastasis in vivo. a The xenograft tumors from the nude mice were exhibited. Each group contained four nude mices. b and c Tumor weights and tumor growth curves were analyzed. d Immunohistochemistry analysis of Ki-67 and ST7L were obtained from tumors (magnification, 400 ×; scale bar, 50 μm). e The expression level of miR-575 in tumors was detected. f and g The mRNA and protein levels of ST7L in tumors were assessed. h The liver and lung collected from orthotopic tumor models were exhibited. Each group contained four nude mices. i and j Representative images of H&E reveal tumor metastases in the liver and lung of nude mice (magnification, 200 ×; scale bar, 125 μm). k The number of liver nodules was calculated. l The percentage of mice with presence (metastatic lesion ≥1) or absence (metastatic lesion = 0) of lung metastasis was detected. (*P < 0.05, **P < 0.01 versus pcDNA3.1 group; #P < 0.05, ##P < 0.01 versus sh-NC group)

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