Fig. 3

MKRN2 regulates cell migration and invasion through the PI3K/Akt pathway. a MKRN2 expression following knockdown of PI3K levels. b, c Changes in the expression of PI3K/Akt-related proteins in b A549 and c H1299 cells. Relative quantification analysis was based on grayscale values. *P < 0.05; **P < 0.01. d Changes in the migration and invasion activity of A549 and H1299 cells in the presence or absence of treatment with the PI3K inhibitor LY294002 and transfection with si-MKRN2. *P < 0.05; **P < 0.01