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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

Fig. 1

ATG5 expression correlated positively with TSSC3 expression in osteosarcoma and predicts a favorable prognosis. a Representative images (200× and 400×) of immunohistochemistry (IHC) positive or negative staining for TSSC3, ATG5, and P62 in human osteosarcoma tissues. A mass of yellow or brown color in tumor cells is considered as a positive staining. Scale bars: 50 μm. b Higher IHC scores of ATG5, which symbolized protein expression intensity, was found in patients with TSSC3(+) osteosarcoma compared with that in patients with TSSC3(−) osteosarcoma. There was no significant correlation between TSSC3 and P62. *P < 0.05. d Kaplan–Meier curves showing that positive expression of TSSC3 is significantly associated with an improved prognosis and longer overall survival (P < 0.05), e while ATG5 and P62 expression is not (P > 0.05). f Kaplan–Meier curve showing that positive expression for both TSSC3 and ATG5 is significantly associated with a favorable prognosis (P < 0.05)

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