Skip to main content

Table 1 Correlations between TSSC3, ATG5, and P62 expression and the clinicopathological features of osteosarcoma

From: TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

Clinical characteristics Group n TSSC3 P-value# ATG5 P-value# P62 P-value#
Positive negative Positive Negative Positive Negative
Age (years) ≤ 20 33 9 24 0.550 17 16 0.830 21 12 0.1482
21–30 12 5 7   7 5   8 4  
≥ 31 13 3 10   6 7   12 1  
Gender Male 34 7 27 0.082 16 18 0.397 22 12 0.233
Female 24 10 14   14 10   19 5  
Tumor location Limbs 51 16 35 0.352 27 24 0.617 35 16 0.352
Others 7 1 6   3 4   6 1  
Stage IIA 14 6 8 0.335 7 7 0.226 9 5 0.816
IIB 32 9 23   18 14   23 9  
III 12 2 10   5 7   9 3  
Lung metastasis Yes 20 3 17 0.082 10 10 0.849 15 5 0.601
No 38 14 24   20 18   26 12  
Local recurrence Yes 22 3 19 0.040* 11 11 0.837 18 4 0.146
No 36 14 22   19 17   23 13  
Histological type Osteoblastic 34 13 21 0.238 21 13 0.338 26 8 0.352
Fibroblastic 3 0 3   1 2   3 0  
Chondroblastic 18 4 14   7 11   10 8  
Others 3 0 3   1 2   2 1  
Tumor size <  8 cm 41 13 28 0.533 24 17 0.107 28 13 0.533
≥ 8 cm 17 4 13   6 11   13 4  
  1. #Pearson’s χ2 test
  2. *With significant difference (P < 0.05)