TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

Table 1 Correlations between TSSC3, ATG5, and P62 expression and the clinicopathological features of osteosarcoma

Clinical characteristics	Group	n	TSSC3		P-value^#	ATG5		P-value^#	P62		P-value^#
Clinical characteristics	Group	n	Positive	negative	P-value^#	Positive	Negative	P-value^#	Positive	Negative	P-value^#
Age (years)	≤ 20	33	9	24	0.550	17	16	0.830	21	12	0.1482
	21–30	12	5	7		7	5		8	4
	≥ 31	13	3	10		6	7		12	1
Gender	Male	34	7	27	0.082	16	18	0.397	22	12	0.233
Gender	Female	24	10	14		14	10		19	5
Tumor location	Limbs	51	16	35	0.352	27	24	0.617	35	16	0.352
Tumor location	Others	7	1	6		3	4		6	1
Stage	IIA	14	6	8	0.335	7	7	0.226	9	5	0.816
	IIB	32	9	23		18	14		23	9
	III	12	2	10		5	7		9	3
Lung metastasis	Yes	20	3	17	0.082	10	10	0.849	15	5	0.601
Lung metastasis	No	38	14	24		20	18		26	12
Local recurrence	Yes	22	3	19	0.040^*	11	11	0.837	18	4	0.146
Local recurrence	No	36	14	22		19	17		23	13
Histological type	Osteoblastic	34	13	21	0.238	21	13	0.338	26	8	0.352
	Fibroblastic	3	0	3		1	2		3	0
	Chondroblastic	18	4	14		7	11		10	8
	Others	3	0	3		1	2		2	1
Tumor size	< 8 cm	41	13	28	0.533	24	17	0.107	28	13	0.533
Tumor size	≥ 8 cm	17	4	13		6	11		13	4

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