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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma

Fig. 5

Omics analysis results of the gene expression profiles of PLC-control, PLC-PAR1, PLC-PAR1/thrombin and PLC-PAR1/siTwist1/Thrombin in PLC-PRF-5 cells. a Cluster analysis of mRNA data after normalization was shown as thermal map. The color changes refer the induction of gene expression. Lines indicate the clusters. PLC-PAR1/siTwist1/Thrombin and PLC-control were listed in the same cluster while PLC-PAR1 and PLC-PAR1/thrombin was located in another cluster. b Compared to PLC-control, PAR1 overexpression affects a series of genes participated in the angiogenesis, metastasis, invasion, and tumor differentiation functions. These functions can then be regulated by Twist1 knocking down after PAR1 overexpression

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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