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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia

Fig. 4

Chemotherapy-induced niche perturbs hematopoietic reconstitution of HSCs. a Experimental design to determine the hematopoietic reconstitution of LSK cells isolated from Ctrl+A2D and B-ALL+A2D. b Percentages of donor-derived cells after first competitive reconstitution. n = 5–6 mice per group. c Percentages of donor-derived cells after second transplantation. n = 5 mice per group. d Experimental design to determine the hematopoietic reconstitution of normal LSK-tomato+ cells isolated from the chemotherapy-induced niche of Ctrl+A2D and B-ALL+A2D. e Percentages of tomato+ cells after first competitive reconstitution. n = 5 mice per group. f Percentages of donor-derived cells after second transplantation. n = 5 mice per group. g Flow cytometric analysis of lineage differentiation of LSK in (b). All data in this figure were shown as mean ± SD from three separate experiments. * P ≤ 0.05; ** P < 0.01

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