Fig. 5

M1 to M2 polarization upon disease progression in 4T1 + RAW264.7, 4T1 and RAW264.7 intraductally inoculated mice. a, b Pro-inflammatory/M1-related (IFN-γ, IL-1β, IL-6, MCP-1, MIP-2 and TNF-α) (a) and anti-inflammatory/M2-related cytokine levels (BAFF, G-CSF, IL-4, IL-10 and TGF-β1) (b) at 3 w p.i. in primary tumors/mammary glands from 4T1 + RAW264.7, 4T1 and RAW264.7 inoculated mice (n = 6 tumors/mammary glands for each inoculation group). c, d Pro-inflammatory/M1-related (c) and anti-inflammatory/M2-related cytokine levels (d) at 5 w p.i. in primary tumors/mammary glands from 4T1 + RAW264.7, 4T1 and RAW264.7 inoculated mice (4T1 + RAW264.7 inoculation group: n = 10 tumors; 4T1 inoculation group: n = 7 tumors; RAW264.7 inoculation group: n = 6 mammary glands). All data are presented as the means +/− SEM. NS: not significant, *: P < 0.05, **: P < 0.01, ***: P < 0.001