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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc

Fig. 1

KPNA2 was overexpressed in the glioma tissues and positively correlated with poor prognosis of the glioma patients. a The staining of KPNA2 was scored based on the criteria in the methodology. Data were presented as mean ± s.d. from three independent experiments. P <  0.0001 between every two adjacent pillars. b Immunohistochemical (IHC) images of KPNA2 in the glioma tissues and normal brain tissues were shown (400×). Clinical glioma specimens were classified into four World Health Organization (WHO) grades (I: Pilocytic astrocytomas, II: Astrocytomas, III: Anaplastic astrocytomas, and IV: glioblastomas). c Overall survival and d relapse-free survival of the glioma patients were followed up based on WHO grades(I,II vs. III,IV). P <  0.05 is considered statistically significant. e Correlation of the expressions of KPNA2 and ki-67 in the glioma specimens was shown (P <  0.0001). f Double immunohistological staining of Ki-67 and KPNA2 in the glioblastoma specimen (400×)

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