Fig. 7
From: KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc
Knockdown of c-myc partially reversed the glycolytic reprogramming caused by overexpression of KPNA2. a mRNA levels were determined in the U87 cells transfected with c-myc-shRNA and scrambled shRNA. Each bar represented the mean ± s.d. from three independent experiments. **P < 0.01. b Enzymatic activities of HK, PKM and PFK1 in the U87 cells transfected with c-myc-shRNA, scrambled shRNA, c-myc-shRNA+ wild-type KPNA2, wild-type KPNA2 were examined. Each bar represented the mean ± s.d. from three independent experiments. **P < 0.01, ***P < 0.001. c Lactate production was measured in the indicated cells. Data were presented as the mean ± s.d. from three independent experiments. *P < 0.05. e Relative deoxyglucose uptake was measured in the indicated cells. Each bar represented the mean ± s.d. from three independent experiments. *P < 0.05, ** P < 0.01