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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

Fig. 4

Simvastatin decreases the transcriptional activity of ERRα in colon cancer cells. a Cell proliferation assays at day 3 for the HCT116 and SW480 cells cultured with simvastatin (5 μM and 10 μM) using the Cell Counting Kit-8. b WB for IDH3A, c-Myc and cyclin D1 in the HCT116 and SW480 cells treated with the indicated concentrations of simvastatin (0–20 μM) or DMSO for 48 h. c, d Clonogenic assays and qualitative analysis of the HCT116 and SW480 cells cultured with DMSO or 5 μM simvastatin (or/and 20 ng/μl EGF) at day 7

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