Fig. 10From: Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cellsSchematic depicts a possible mechanism of triptolide inducing apoptosis in EBV-positive NPC cell. The caspase-9 activation plays a critical role in triptolide-induced mitochondria apoptosis in NPC cells. Triptolide inhibits EBNA1 expression through contributing to the proteasome-ubiquitin process and disturbing the stability of EBNA1, which promotes the activation of caspase-9, and induces the apoptotic effect of NPC cellsBack to article page