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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells

Fig. 7

TP at a non-toxic concentration decreases EBNA1 expression in PBMCs and NPC cells. PBMCs were isolated from EBV-positive donors and incubated with DMSO (0.01%)or dose-dependent TP for 96 h. a Cell viability of PBMCs was detected by a CCK-8 assay. b PBMCs were treated with DMSO (0.01%) or TP (40 nM) for 96 h. c HONE1/Akata, CNE1/Akata, HK1/Akata, and C666–1 cells were treated with DMSO (0.01%) or TP (40 nM) for 96 h. Whole-cell extracts were prepared and subjected to Western blot analysis. Quantified analysis of EBNA1 expression in PBMCs (d) or NPC cell lines (e) were performed by Image J. f HONE1/Akata, CNE1/Akata, HK1/Akata and C666–1 cells were treated with DMSO (0.01%) or TP (40 nM) for 0, 48, and 96 h. Cell viability of NPC cells were detected by a CCK-8 assay (*: P < 0.05; **: P < 0.01; ***: P < 0.001)

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