TY - JOUR AU - Chang, Jer-Hwa AU - Cheng, Chao-Wen AU - Yang, Yi-Chieh AU - Chen, Wan-Shen AU - Hung, Wen-Yueh AU - Chow, Jyh-Ming AU - Chen, Pai-Sheng AU - Hsiao, Michael AU - Lee, Wei-Jiunn AU - Chien, Ming-Hsien PY - 2018 DA - 2018/08/22 TI - Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses JO - Journal of Experimental & Clinical Cancer Research SP - 199 VL - 37 IS - 1 AB - Metastasis rather than the primary cancer determines the survival of cancer patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition (EMT), the initial step in lung cancer metastasis. Apigenin (API), a flavonoid with a potent Akt-inhibitory effect, shows oncostatic activities in various cancers. However, the effects of API on metastasis of non-small cell lung cancer (NSCLC) remain unclear. SN - 1756-9966 UR - https://doi.org/10.1186/s13046-018-0869-1 DO - 10.1186/s13046-018-0869-1 ID - Chang2018 ER -