Fig. 3
NPC-PDX drug screening. (a-f) PDX-Bone (NPC13-F4 corresponds to patient no.13 derived bone metastatic NPC tumor was transplanted in NOD/SCID mice at 4th passage); (a, b) Mice gross tumor, (c) tumor volume, (d) tumor weight, (e) mice body weight change, and (f) cyclin D1 IHC and EBER staining in control (DMSO) and GEM and PAL treatment. (g-h) PDX-LN (NPC02-F11 corresponds to patient no.2 derived lymph node metastatic NPC tumor was transplanted in NOD/SCID mice at 11th passage), (g) tumor volume, (h) tumor weight. Abbreviation: GSK, GSK126; DEC, decitabine; GEM, gemcitabine; PAL, palbociclib. (Raw data was provided in Additional file 17: Table S9 A-D)