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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88

Fig. 6

AGAP2-AS1 facilitates trastuzumab resistance via MyD88 in vivo. a Images of tumors that developed in xenograft transplanted nude mouse tumor models treated by administering 5 mg/kg trastuzumab or PBS (for control group) intraperitoneally once every 2 days for 3 weeks in different groups. Four treatment groups of mice xenograft were established: Group I (Lv-NC-transfected cells + PBS), Group II (Lv-AGAP2-AS1-transfected cells + PBS), Group III (Lv-NC-transfected cells + trastuzumab treatment) and Group IV (Lv- AGAP2-AS1-transfected cells + trastuzumab treatment). Six mice were included in each group and more than three mice remained after the treatment regimen excluding mice that were dead or with complications, such as skin necrosis due to infection. b Weights of tumors that developed in xenografts from different groups are shown. c IHC analysis of expression levels of MyD88 in respective groups. d Images of tumors that developed in xenograft transplanted nude mouse tumor models treated orally with 5 mg/kg gefitinib once daily for 3 weeks in different transfection groups. *p < 0.05, **p < 0.01

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