Fig. 1

Expression of miR-452 in colorectal cancer. a, real-time quantitative PCR analysis of miR-452 expression in 43 paired human CRC tissues and their corresponding adjacent normal tissues; miR-452 expression was normalized to that of U6. b, relative expression of miR-452 in 43 normal and 74 CRC tissues. The Mann-Whitney test was used (p < 0.0001). c, miR-452 expression in normal colorectal tissues relative to CRC tissues with a stage 1–2 clinical classification; Student’s t-test was used (p < 0.05). d, correlation between miR-30b expression and distant metastasis. Correlation between miR-452 expression and survival by Kaplan-Meier analysis of CRC patients with high (≥ median; n = 37) or low (< median; n = 36) miR-452 expression (p < 0.05)