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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Fig. 1

Chemotherapy agents promote HSP90AA1 expression in osteosarcoma cells. a and b, MG-63, Saos-2 and U-2 OS cells were treated with Cis (20 μmol/L), Dox (0.2 μg/mL), and Mtx (50 μmol/L) for 24 h. Whole cell lysates were subjected to western blot analysis for HSP90AA1 expression (a) and HSP90AA1 mRNA level was assessed by quantitative real-time PCR (b; n = 3; *, p < 0.05 versus untreated group). c MG-63 and U-2 OS cells were treated with Dox (0.2 μg/mL) for 12 to 48 h and then HSP90AA1 protein level was assessed by Western blot

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