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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Fig. 6

Suppression of HSP90AA1 increases sensitivity to chemotherapy in vivo. a NOD/SCID mice were inoculated with control shRNA/HSP90AA1 shRNA transfected MG-63 cells. At the beginning at day 7, docetaxel (5 mg/kg) was administered via intraperitoneal injection. a tumor volumes were calculated for 28 days (n = 3; *p < 0.05). Representative photographs of tumors formed at 4 weeks are shown. b Apoptosis and autophagy in tumor tissues were detected by TUNEL and LC3 stain respectively after insection of tumor samples

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