Fig. 6From: HSP90AA1-mediated autophagy promotes drug resistance in osteosarcomaSuppression of HSP90AA1 increases sensitivity to chemotherapy in vivo. a NOD/SCID mice were inoculated with control shRNA/HSP90AA1 shRNA transfected MG-63 cells. At the beginning at day 7, docetaxel (5 mg/kg) was administered via intraperitoneal injection. a tumor volumes were calculated for 28 days (n = 3; *p < 0.05). Representative photographs of tumors formed at 4 weeks are shown. b Apoptosis and autophagy in tumor tissues were detected by TUNEL and LC3 stain respectively after insection of tumor samplesBack to article page