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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Fig. 7

Proposed model of the mechanism of HSP90AA1 gene in osteosarcoma drug resistance. Chemotherapy increases the expression level of HSP90AA1, which leads to disassociation of phosphorylated AKT and JNK/P38. The dephosphorylation of AKT decreases the expressions of phosphorylation of mTOR and promotes autophagy. The dephosphorylation of JNK/P38 results in decreased apoptosis. Moreover, autophagy also can influence HSP90AA1-mediated antiapoptotic effect. Therefore, HSP90AA1 is a critical factor in the development of osteosarcoma chemoresistance

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