Fig. 7From: HSP90AA1-mediated autophagy promotes drug resistance in osteosarcomaProposed model of the mechanism of HSP90AA1 gene in osteosarcoma drug resistance. Chemotherapy increases the expression level of HSP90AA1, which leads to disassociation of phosphorylated AKT and JNK/P38. The dephosphorylation of AKT decreases the expressions of phosphorylation of mTOR and promotes autophagy. The dephosphorylation of JNK/P38 results in decreased apoptosis. Moreover, autophagy also can influence HSP90AA1-mediated antiapoptotic effect. Therefore, HSP90AA1 is a critical factor in the development of osteosarcoma chemoresistanceBack to article page