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Table 1 Multivariate Cox regression analyses of the significant of different prognostic variables in nasopharyngeal carcinoma

From: TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma

  Overall survival Disease-free survival Distant metastasis-free survival
Variable HR 95%CI p-value HR 95%CI p-value HR 95%CI p-value
Training set
 TIPE3 methylation level (High vs. Low) 2.99 1.59–5.64 0.001 2.56 1.35–4.85 0.004 2.91 1.24–6.28 0.014
 TNM stage (III-IV vs. I-II) 2.00 1.13–3.54 0.018 1.86 1.03–3.38 0.041 2.68 1.14–6.28 0.023
 Age (> 45 years vs. ≤45) 2.05 1.33–3.17 0.001 1.64 1.05–2.56 0.031 2.53 1.40–4.57 0.002
Validation set
 TIPE3 methylation level (High vs. Low) 1.80 1.02–3.16 0.041 1.71 1.01–2.89 0.045 2.69 1.21–5.96 0.015
 TNM stage (III-IV vs. I-II) 3.30 1.41–7.71 0.006 3.19 1.45–7.01 0.004 3.71 1.13–12.18 0.030