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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)

Fig. 2

Relative miR-4317 expression levels in NSCLC tissues and serum and its clinical significance. a Expression levels of miR-4317 in 162 paired NSCLC and corresponding noncancerous tissues measured by in situ hybridization. b Kaplan-Meier overall survival curves by high and low miR-4317 expression in 162 NSCLC patients. c Quantitation of miR-4317 was performed using qRT-PCR in 140 paired NSCLC (T) and corresponding normal tissues (N). The fold changes were calculated by relative quantification (2−∆Ct, U6 as the internal control). d, e miR-4317 expression was detected in lymph node metastasis (d) and different clinical stages (e) of NSCLC. f Kaplan-Meier curves depicting overall survival according to the expression of miR-14,317 as validation. g The expression level of serum miR-4317 in 86 NSCLC patients and 40 healthy controls was measured by qRT-PCR and normalized to U6. h, i miR-4317 expression was detected in lymph node metastasis (h) and different clinical stages (i). j Receiver-operating characteristic curve analysis of the miR-4317 assay ratio for detecting NSCLC patients. ♦p < 0.05

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