Fig. 3
From: HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair
HMGB1 knockdown increased Dex-induced MM cell apoptosis. a: RPMI8226 and CAG were treated with Dex for 48 h, and cell cycle distribution was detected by flow cytometry (n = 3, p > 0.05); b: Representative flow cytometry results showing RPMI 82286 (transfected with control shRNA or HMGB1 shRNA) apoptosis after treatment with Dex (100 μM) for 48 h; c: Histograms showing the results of the analysis of cell apoptosis induced by Dex (n = 3); d: Western blotting was performed to detect the expression of c-caspase-3 and c-PARP induced by Dex after HMGB1 knockdown; e: Histograms showing the densitometric analysis of the 15 KD fragment of c-caspase-3 (*P<0.05,**P<0.01,***P<0.001)