Fig. 6
From: HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair
DNA damage induced by Dex was increased after HMGB1 knockdown. a, c: Western blotting was performed to evaluate the expression of the DNA damage and repair related proteins Rad51 (a) and γH2A.X (c), respectively, after HMGB1 knockdown with or without Dex exposure for 48 h; b, d:Densitometric analysis of Rad51 (b) and γH2A.X (d); e: Histograms showing the analysis results of RPMI8226 (transfection with control shRNA or HMGB1 shRNA) apoptosis induced by Dex (100 μM) in presence of AZD6738 (2 μM, an ATR inhibitor) (*P<0.05,**P<0.01,***P<0.001)