Fig. 5
From: Endothelial cells promote metastasis of prostate cancer by enhancing autophagy
Drugs targeting CCL5/CCR5 and autophagy reduce metastasis in vivo. a In vivo bioluminescence imaging monitoring metastasis in orthotopic xenograft models. C4–2 cells was coimplanted with HUVEC. Mice were treated with CQ or Maraviroc alone or CQ + Maraviroc combination. b Overall survival of mice at the end of experiment. c Immunohistochemistry staining of AR and Paxillin in xenografts