Fig. 3

Gdf2 deletion increases metastatic burden in the E0771 mammary cancer model. E0771 cells were injected in the 4th mammary gland of WT and Gdf2^−/− mice and lung metastases were analyzed 9 days after tumor detection. a Representative hematoxylin eosin colorations of metastases within WT and Gdf2^−/− lungs. Scale bar 250 μm. b Total area, (c) number and (d) mean size of lung metastases per mice bearing metastases (WT n = 7, Gdf2^−/− n = 10, 1 representative experiment out of 3). b, c, d Data are the median ± interquartile range. Statistical analysis: Mann-Whitney test. *p ≤ 0.05 significantly different