Skip to main content
Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

Fig. 3

MAPK and AKT signaling pathways are involved in CA apoptotic effect on human PCa cells. MAPKs (a) and AKT (d) protein expressions were analyzed using western blot. Densitometry scanning analysis for ratio of p-JNK/total JNK, p-P38/total P38 and p-ERK1/2/total ERK1/2 (b) as well as p-AKT/total AKT (e). Data represent the mean ± SD of three independent experiments. *p < 0.05 and **p < 0.01 as compared with untreated control. c Effects of SP600125, SB203580 and LY294002 (f) CA-induced apoptosis in cultured cells for 24 h. Cell viability was determined by MTT assay and data represent the mean ± SD of six experiments in each group. *p < 0.05, **p < 0.01 as compared with single CA treated cells

Back to article page