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Table 2 Regulation of PTEN expression by lncRNAs

From: Regulation of PTEN expression by noncoding RNAs

LncRNA PTEN expression Mechanism MiRNA Disease Reference
PTENP1 Up acting as ceRNAs miR-21, miR-17, miR-214, miR-19, miR-20, miR-93, miR-106b, miR-26 CCRCC, OSCC, HCC, Gastric cancer [54, 96,97,98,99,100,101]
HOTAIR Up acting as ceRNAs miR-19 Cardiac hypertrophy [105]
Linc-USP16 Up acting as ceRNAs miR-21,miR-590-5p HCC [106]
LncRNA-BGL3 Up acting as ceRNAs miR-17, miR-20a, miR-20b, miR-93, miR-106a Chronic myeloid leukemia [80]
CASC2 Up acting as both ceRNAs and downregulators of miRNAs miR-21, miR-181a Osteosarcoma, Glioma, Cervical cancer [107,108,109]
MEG3 Up acting as both ceRNAs and downregulators of miRNAs miR-1297, miR-19a, miR-21 Breast cancer, Glioma, CAD [111,112,113]
lncRNA GAS5 Up acting as both ceRNAs and downregulators of miRNAs miR-21, miR-103, miR-196a, miR-205, miR-32-5p HER2-positive breast cancer, HCC, NSCLC, Cardiac fibrosis, Endometrial cancer, Cervical cancer, Pancreatic cancer [114,115,116,117,118,119,120]
XIST Up acting as both ceRNAs and downregulators of miRNAs miR-181a, MiR-494 HCC, Spinal Cord Injury [121, 122]
NBAT1 Up acting as both ceRNAs and downregulators of miRNAs miR-21 Osteosarcoma [123]
lnc-2 /lnc-6 Up acting as both ceRNAs and downregulators of miRNAs miR-26a Prostate cancer, Glioma [126, 127]
FER1L4 Up acting as both ceRNAs and downregulators of miRNAs miR-106a-5p Colon cancer, Gastric cancer [130, 131]
lincRNA-p21 Up acting as both ceRNAs and downregulators of miRNAs miR-181b Liver fibrosis [132]
PTENP1 asRNA β Up increasing the stability and miRNA sponge activity of PTENP1 [133]
HOTAIR Down enhancing PTEN methylation via miRNA sponging miR-29b Liver Fibrosis, LSCC [134, 135]
PTENP1 asRNA α Down enhancing PTEN methylation via the recruitment of DNMT3a and EZH2 [133]