Table 2 Regulation of PTEN expression by lncRNAs

PTENP1

Up

acting as ceRNAs

miR-21, miR-17, miR-214, miR-19, miR-20, miR-93, miR-106b, miR-26

CCRCC, OSCC, HCC, Gastric cancer

[54, 96,97,98,99,100,101]

HOTAIR

Up

acting as ceRNAs

miR-19

Cardiac hypertrophy

[105]

Linc-USP16

Up

acting as ceRNAs

miR-21,miR-590-5p

HCC

[106]

LncRNA-BGL3

Up

acting as ceRNAs

miR-17, miR-20a, miR-20b, miR-93, miR-106a

Chronic myeloid leukemia

[80]

CASC2

Up

acting as both ceRNAs and downregulators of miRNAs

miR-21, miR-181a

Osteosarcoma, Glioma, Cervical cancer

[107,108,109]

MEG3

Up

acting as both ceRNAs and downregulators of miRNAs

miR-1297, miR-19a, miR-21

Breast cancer, Glioma, CAD

[111,112,113]

lncRNA GAS5

Up

acting as both ceRNAs and downregulators of miRNAs

miR-21, miR-103, miR-196a, miR-205, miR-32-5p

HER2-positive breast cancer, HCC, NSCLC, Cardiac fibrosis, Endometrial cancer, Cervical cancer, Pancreatic cancer

[114,115,116,117,118,119,120]

XIST

Up

acting as both ceRNAs and downregulators of miRNAs

miR-181a, MiR-494

HCC, Spinal Cord Injury

[121, 122]

NBAT1

Up

acting as both ceRNAs and downregulators of miRNAs

miR-21

Osteosarcoma

[123]

lnc-2 /lnc-6

Up

acting as both ceRNAs and downregulators of miRNAs

miR-26a

Prostate cancer, Glioma

[126, 127]

FER1L4

Up

acting as both ceRNAs and downregulators of miRNAs

miR-106a-5p

Colon cancer, Gastric cancer

[130, 131]

lincRNA-p21

Up

acting as both ceRNAs and downregulators of miRNAs

miR-181b

Liver fibrosis

[132]

PTENP1 asRNA β

Up

increasing the stability and miRNA sponge activity of PTENP1

–

–

[133]

HOTAIR

Down

enhancing PTEN methylation via miRNA sponging

miR-29b

Liver Fibrosis, LSCC

[134, 135]

PTENP1 asRNA α

Down

enhancing PTEN methylation via the recruitment of DNMT3a and EZH2

–

–

[133]