Fig. 7From: An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancerHigh efficacy of FL118 inhibition of pancreatic cancer PDX alone or in combination of gemcitabine: Pancreatic cancer PDX tumors were maintained on severe Combined Immunodeficiency (SCID) mice. Experimental SCID mice were subcutaneously implanted with individual pancreatic cancer PDX tumors at the flank area of mice. Seven to 14 days after the implanted tumors grew to 100–300 mm3 (designated as day 0), FL118 was administrated via ip with a dose of about half maximum tolerated dose (1/2MTD, 5 mg/kg) (a, b, c) or with a dose of 0.75 mg/kg in combination with gemcitabine at 60 mg/kg (~ 1/2MTD) (d) weekly for 4 times (qw × 4) as shown (arrows). a, Pancreatic cancer PDX14244 tumors. b, Results from pancreatic cancer PDX17624 tumors. c and d, Results from pancreatic cancer PDX10978 tumors. Each curve represents mean ± SD derived from five mice (5 mice per group). e, The same data shown in the Fig. 7d were presented in the tumor volume format to show the really size of the tumor during the experimentsBack to article page