Fig. 8

Effects of FL118 on animal body weight changes during treatment: a, Effects of FL118 on the body weight change of BALB/cj mice. Results from vehicle and FL118 MTD dosing level (10 mg/kg) were shown with oral route via qw × 4 (arrowed). The body weigh curves were derived from the mean ± SD derived from 6 independent BALB/cj mice. b and c, Effects of FL118 on the body weight change of beagle dogs. Results from vehicle and FL118 at 0.55 mg/kg (1/4MTD), 1.1 mg/kg (1/2MTD) and 2.2 mg/kg (MTD) dosing levels were shown with oral administration of FL118 on Days 1 and 8. The body weigh histograms were derived from the mean ± SD derived from 2 male or 2 female beagle dogs