Table 1 Effects of FL118 on BALB/cj mouse hematological parameters

RBC ^a (M/μL)

HGB (g/dL)

HCT (%)

MCV (fL)

MCH (pg)

MCHC (g/dL)

RDW-SD (fL)

RET (K/μL)

Normal range

3.75–15.2

6.1–21.7

16.7–69.8

39–90.8

12.6–31

27–37.6

24.2–63.1

3.6–15.2

Vehicle

7.51–9.06

11.1–13.7

33.5–40.6

44.6–44.2

14.8–15.1

33.1–34

26.4–28.9

5.13–6.4

FL118 (MTD)

6.01–7.04

8.9–10.8

26.1–30.9

41.9–43.9

14.8–15.3

33.7–36

23–24.8

0.67–4.49

PLT (K/μL)

PDW (fL)

MPV (fL)

WBC (K/μL)

NEUT (K/μL)

LYM (K/μL)

MONO (K/μL)

EOS (K/μL)

BASO (K/μL)

Normal range

59–2633

5.7–23.9

5.2–13.1

1.1–56.1

0.03–32.1

0.12–23.5

0–5.1

0–2.1

0–2.3

Vehicle

179–290

7–11.2

5.5–7.6

4.0–8.5

3.6–5.7

0.31–1.73

0.26–0.95

0.01–0.12

0–0.01

FL118 (MTD)

487–1004

13.8–14.4

8.1–8.6

0.33–0.6

0.03–0.5

0.06–0.17

0.03–0.12

0.01–0.1

0