Table 3 Effects of FL118 on beagle dogs’ hematological parameters
|  | RBC (M/μL) | HGB (g/dL) | HCT (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | RDW (%) | RET (K/μL) | PLT (K/μL) | WBC (K/μL) |
Vehicle TX | ||||||||||
 pre-dosing | 5.4–7.2 | 12.5–16.1 | 37.6–48.3 | 67–69.4 | 22–23.1 | 32.7–33.3 | 12.7–13.4 | 18.4–30.7 | 321–389 | 9.2–10.9 |
 after dosing | 6.0–6.7 | 13–14 | 39.4–44.3 | 66.3–68.7 | 21.7–23 | 32.8–34 | 12.6–13.3 | 14.1–34.5 | 256–283 | 9.8–14.1 |
FL118 (MTD) | ||||||||||
 pre-dosing | 5.1–5.9 | 11.8–13.2 | 35.4–40.2 | 67.4–69.3 | 22–23.2 | 33–33.5 | 13.4–13.4 | 11.6–45.3 | 318–386 | 7.1–8.7 |
 after dosing | 5.2–6.0 | 12–13.8 | 35.4–40 | 66–68.2 | 22.5–23 | 33.7–34.7 | 12.4–13.5 | 3.7–25.9 | 219–267 | 5.2–9.9 |
|  | NEUT (K/μL) | LYM (K/μL) | MONO (K/μL) | EOS (K/μL) | BASO (K/μL) | LUC a (K/μL) | PT (sec) | APTT (sec) | FIB (mg/dL) |  |
Vehicle TX | ||||||||||
 pre-dosing | 5.0–6.4 | 2.3–3.5 | 0.6–0.9 | 0.23–0.5 | 0.05–0.1 | 0.01–0.03 | 6.1–7.7 | 10.9–11.1 | 194–234 |  |
 after dosing | 5.9–9.0 | 3.1–3.9 | 0.5–1.0 | 0.13–0.5 | 0.05–0.15 | 0.02–0.05 | 5.8–6.9 | 10.4–12 | 202–236 |  |
FL118 (MTD) | ||||||||||
 pre-dosing | 3.7–5.2 | 2.4–3.7 | 0.5–0.6 | 0.18–0.26 | 0.05–0.1 | 0.02–0.05 | 6.1–6.9 | 10.5–11.7 | 209–313 |  |
 after dosing | 3.2–9.0 | 1.6–3.0 | 0.1–0.41 | 0.06–0.28 | 0.01–0.03 | 0.00–0.01 | 5.6–6.4 | 10.1–11.2 | 210–364 |  |