Table 4 Effects of FL118 on beagle dogs’ serum biochemical parameters
| Â | GLU (mg/dL) | BUN (mg/dL) | CREA (mg/dL) | TP (g/dL) | ALB (g/dL) | GLOB b (g/dL) | A:G Ratio | CHOL (mg/dL) | TRIG (mg/dL) | TBIL (mg/dL) |
Vehicle TX | ||||||||||
 pre-dosing | 68–91 | 9–13 | 0.2–0.4 | 4.7–5.2 | 3.2–3.6 | 1.5–1.7 | 1.9–2.3 | 133–160 | 37–48 | ≤ 0.1 |
 after dosing | 84–98 | 11–17 | 0.4 | 5.0–5.3 | 3.0–3.3 | 2.0–2.1 | 1.5–1.7 | 116–171 | 40–55 | ≤ 0.1 |
FL118 (MTD) | ||||||||||
 pre-dosing | 72–93 | 9–13 | 0.3–0.4 | 4.8–5.2 | 3.3–3.4 | 1.5–1.9 | 1.7–2.2 | 112–206 | 34–45 | <  0.1 |
 after dosing | 87–105 | 12–20 | 0.4 | 4.7–5.2 | 2.8–3.2 | 1.8–2.1 | 1.5–1.8 | 119–195 | 18–46 | ≤ 0.1 |
| Â | AST (U/L) | ALT (U/L) | ALP (U/L) | GGT (U/L) | CK (U/L) | Ca (mg/dL) | PHOS (mg/dL) | Na (mmol/L) | K (mmol/L) | Cl (mmol/L) |
Vehicle TX | ||||||||||
 pre-dosing | 29–36 | 33–49 | 87–132 | <  3 | 302–524 | 10.8–11.1 | 6.7–8.0 | 143–148 | 4.6–5.0 | 104–106 |
 after dosing | 34–88 | 41–46 | 96–129 | <  3 | 387–4171 | 10.4–10.8 | 6.4–7.7 | 146–147 | 4.7–5.1 | 105–108 |
FL118 (MTD) | ||||||||||
 pre-dosing | 31–39 | 29–41 | 103–116 | <  3 | 339–457 | 11–11.5 | 7.1–8.1 | 145–148 | 4.9–5.3 | 105–109 |
 after dosing | 40–48 | 23–51 | 81–106 | <  3 | 410–794 | 10.2–10.7 | 6.1–7.0 | 146–148 | 4.5–4.9 | 108–112 |