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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo

Fig. 2

The mechanisms of US-mediated ADM accumulation. a Cell morphology and cytomembrane changes after US exposure (scale bar = 5 μm); (b) The dynamic change of ADM concentration in MCF-7/ADR and HEPG2/ADM cells treated with ADM immediately after US exposure; N = 3; data are represented as mean ± s.d; *P < 0.05; (c) Q-PCR of drug efflux transporters mRNA in MCF-7/ADR and HEPG2/ADM cells in 24 h after US exposure or not; N = 3; data are represented as mean ± s.d; *P < 0.05; (d) Immunoblotting of P-gp expression in 24 h after US exposure; N = 3; data are represented as mean ± s.d; *P < 0.05; (e) The dynamic change of ADM concentration in MCF-7/ADR and HEPG2/ADM cells treated with US+ADM or ADM alone. ADM was added to the mediums in 24 h after exposure to US; N = 3; data are represented as mean ± s.d; *P < 0.05

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