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Table 2 Major findings of tumor-derived exosomes in NSCLC

From: The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Contents Findings References
Invasion exosomal TGF-β and IL-10 may enhance migration ability in vitro under hypoxia [47]
exosomal vimentin may induce EMT [51]
exosomal Rab3D which activates AKT/GSK3β signaling may induce EMT [52]
exosomal miR-23a may affect the changes of EMT related phenotype [53]
Exosomal miR-302b can inhibit the proliferation and migration of lung cancer cells through the TGFβRII/ERK pathway [54]
Drug resistance exosomal VEGF and TGF2β may result in drug resistance [61, 62]
exosomal proteins and phospholipids components are involved in gefitinib resistance [63, 64]
exosomes may antagonize the chemotherapeutic effect of cisplatin by upregulating autophagy [65]
exosomes can regulate the combination of antibody targeting drugs and tumor cells [71, 72]