The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Table 2 Major findings of tumor-derived exosomes in NSCLC

Contents	Findings	References
Invasion	exosomal TGF-β and IL-10 may enhance migration ability in vitro under hypoxia	[47]
	exosomal vimentin may induce EMT	[51]
	exosomal Rab3D which activates AKT/GSK3β signaling may induce EMT	[52]
	exosomal miR-23a may affect the changes of EMT related phenotype	[53]
	Exosomal miR-302b can inhibit the proliferation and migration of lung cancer cells through the TGFβRII/ERK pathway	[54]
Drug resistance	exosomal VEGF and TGF2β may result in drug resistance	[61, 62]
	exosomal proteins and phospholipids components are involved in gefitinib resistance	[63, 64]
	exosomes may antagonize the chemotherapeutic effect of cisplatin by upregulating autophagy	[65]
	exosomes can regulate the combination of antibody targeting drugs and tumor cells	[71, 72]