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Table 3 Tumor-derived exosomes in the targeted therapy of NSCLC

From: The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Potential value Methods References
A tool for drug delivery Use electroporation or lipofection [106,107,108,109,110]
A direct target for reducing the content Blood purification: ADAPT, hollow fiber filtration technology Change the local pH of the tumor: PPIs Drug usage: GW4869, amiloride, diannexin Interfere with signal pathway: knockout Rab27, SYTL4 ,EXPH5, ISGylation and syndecan-syntenin-ALIX [24, 110,111,112,113,114,115,116,117,118]
Other targets let-7, LKB1, CD9, CD63, surviving, miR-302b [54, 119,120,121,122,123,124,125,126]