Fig. 3

LMO3 knockdown suppresses the metastasis of HCC cells in vivo. a Representative photos of liver tissues from mice orthotopically inoculated with LMO3 silenced SMMC-7721 and control cells (n = 5 each group). b Statistical analysis of intrahepatic metastatic tumor volume is shown right. c Mice survival of LMO3 silenced SMMC-7721 and control group (n = 10 each group) (P < 0.001). d Representative images of H&E staining in liver tissues from mice orthotopically inoculated with LMO3 silenced SMMC-7721 and control cells (n = 5 each group). Scale bars: 10 μm. e Statistical analysis of intrahepatic metastatic focis in the two groups is shown below. f Pulmonary metastases were detected by H&E staining (n = 6 each group). Scale bars: 10 μm. g Statistical analysis of numbers of pulmonary metastatic nodules is shown below. **P < 0.01