Fig. 6From: LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signalingHippo pathway inhibitors abrogate recombinant LMO3 protein induced HCC cell invasion and anoikis inhibiton. a and b Huh-7 and SNU-423 cells were treated with 50Ā nM rLMO3 protein, 50Ā nM rLMO3 protein plus 50Ā nM Verteporfin (the inhibitor of YAP-TEAD), 50Ā nM rLMO3 protein plus 50Ā nM Peptide 17 (the inhibitor of YAP-TEAD) respectively. The invaded Huh-7 (a) and SNU-423 (b) cells were analyzed after 48Ā h. Scale bars: 10Ā Ī¼m. c and d Huh-7 and SNU-423 cells were treated with 50Ā nM rLMO3 protein, 50Ā nM rLMO3 protein plus 50Ā nM Verteporfin, 50Ā nM rLMO3 protein plus 50Ā nM Peptide 17 respectively. The apoptotic Huh-7 (c) and SNU-423 (d) cells were analyzed after 48Ā h. *Pā<ā0.05, **Pā<ā0.01. e LMO3 promoted HCC cell invasion and anoikis inhibition by interacting with LATS1 and suppressing Hippo signalingBack to article page