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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling

Fig. 6

Hippo pathway inhibitors abrogate recombinant LMO3 protein induced HCC cell invasion and anoikis inhibiton. a and b Huh-7 and SNU-423 cells were treated with 50Ā nM rLMO3 protein, 50Ā nM rLMO3 protein plus 50Ā nM Verteporfin (the inhibitor of YAP-TEAD), 50Ā nM rLMO3 protein plus 50Ā nM Peptide 17 (the inhibitor of YAP-TEAD) respectively. The invaded Huh-7 (a) and SNU-423 (b) cells were analyzed after 48Ā h. Scale bars: 10Ā Ī¼m. c and d Huh-7 and SNU-423 cells were treated with 50Ā nM rLMO3 protein, 50Ā nM rLMO3 protein plus 50Ā nM Verteporfin, 50Ā nM rLMO3 protein plus 50Ā nM Peptide 17 respectively. The apoptotic Huh-7 (c) and SNU-423 (d) cells were analyzed after 48Ā h. *Pā€‰<ā€‰0.05, **Pā€‰<ā€‰0.01. e LMO3 promoted HCC cell invasion and anoikis inhibition by interacting with LATS1 and suppressing Hippo signaling

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