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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation

Fig. 5

TMZ-POH impairs mitochondria elimination. a Statistical analysis of the percentage of punctate GFP signals that were positive for mRFP in A549 and SPC-A1 cells (b) A549 and H460 cells treated with NAM, Baf.A1 and TMZ-POH were loaded with MTG probe and subjected to flow cytometry. Mean fluorescence intensity (Geom Mean) of MTG was statistically analyzed. c A549 cells treated with CCCP or TMZ-POH were labelled with LTR and MTR and inspected under confocal laser microscopy. The colocalization coefficient of LTR and MTG was statistically analyzed. The results shown are means ±SD, *p < 0.05, **p < 0.005, ***p < 0.001

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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