Fig. 8

TMZ-POH induces apoptosis enhanced by 3-MA, and increases irradiation-induced apoptosis. a A549 and SPC-A1 cells were incubated with 3-MA (1 mM) combined with TMZ-POH (100 μM) for 48 h, and finally subjected to apoptosis analysis; b The percent of the dead cells was statistically analyzed. c A549 and H520 cells were subjected to 10 Gy irradiation for 72 h, and were treated with 25 or 50 μM TMZ-POH during the last 48 h, an apoptosis analysis was applied; d The percent of the dead cells was statistically analyzed. The results shown are means ±SD, *p < 0.05, **p < 0.005, ***p < 0.001