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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Fig. 3

JPH203 decreases mTORC1 activity, but not ERK or AKT Western blot analyses of mTORC1, ERK and AKT activity in thyroid cancer cell lines after JPH203 treatment. P-p70 S6 kinase, p-ERK and p-AKT levels were assayed in (a) PTC cell lines and (b) ATC cell lines and (c) LNCaP as negative control. Cells were plated in triplicates using normal growth medium, after overnight incubation cells were washed and 0.125X EAA was added. Cells were treated with 10 μM JPH203 or DMSO as control and lysed after 24 h

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