Fig. 5
From: The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model
The inhibition of LAT1 by JPH203 induces a cytostatic growth arrest in an ATC mouse model in vivo. a Outline of experimental procedure, as described in the text. b Representative ultrasound images of vehicle- and JPH203-treated mice at day 0 and day 45. Images display the largest thyroid cross-section, marked with the red line, at each time point. c Quantification of the weekly acquired US images of vehicle- (n = 4) and JPH203-treated (n = 5) mice during the 45 days of treatment. Mice were treated for 5 consecutive days/week with either 50 mg/kg JPH203 or vehicle (Captisol®) by i.p. injection. The largest thyroid cross-section was analyzed once per week and normalized to the largest thyroid cross-section measured on day 0. Statistical analysis was performed using a two-way ANOVA test with Bonferroni correction for multiple comparisons. d Body weight was measured every week and normalized to the initial weight at day 0