Fig. 2
From: The role of cellular reactive oxygen species in cancer chemotherapy
Different chemotherapeutics have distinct mechanisms of action, the diagram represents the cellular mechanisms by which the main classes of chemotherapeutics exhibit their effects. Some chemotherapies, in blue text, impacting ROS production in the cell while others, in orange text, regulate ROS by inhibiting their detoxification by cellular antioxidants. Altered balance of cancer ROS production and removal by chemotherapeutic modulation dictates the final level of ROS and the ultimate outcome of ROS effect