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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis

Fig. 5

The expression levels and the correlation between MLK7-AS1 and YAP1. (a, b) The mRNA and protein expression levels of YAP1 were significantly elevated in ovarian cancer tissue samples compared with adjacent normal tissues. (c, d) The mRNA and protein expression levels of YAP1 were significantly decreased by the MLK7-AS1 knockdown in ovarian cancer cell lines. (e, f) YAP1 levels were greatly decreased by the MLK7-AS1 knockdown in ovarian cancer cell lines using immunofluorescence. (g) MLK7-AS1 mRNA expression greatly reduced by YAP1 knockdown in SKOV3, OVCAR3, and PEO1 cell lines. (h) pcDNA3.1/YAP1 was transfected into SKOV3, OVCAR3, and PEO1 cell lines to get YAP1 overexpression, and the effects were verified using western blot. (i) The inhibition effects of MLK7-AS1 knockdown on cell growth were partly reversed by YAP1 overexpression using MTT assay. The data were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01

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