TY - JOUR AU - Vaupel, P. AU - Kallinowski, F. AU - Okunieff, P. PY - 1989 DA - 1989// TI - Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review JO - Cancer Res VL - 49 ID - Vaupel1989 ER - TY - JOUR AU - Wike-Hooley, J. L. AU - Haveman, J. AU - Reinhold, H. S. PY - 1984 DA - 1984// TI - The relevance of tumour pH to the treatment of malignant disease JO - Radiother Oncol VL - 2 UR - https://doi.org/10.1016/S0167-8140(84)80077-8 DO - 10.1016/S0167-8140(84)80077-8 ID - Wike-Hooley1984 ER - TY - JOUR AU - Fukamachi, T. AU - Ikeda, S. AU - Wang, X. AU - Saito, H. AU - Tagawa, M. AU - Kobayashi, H. PY - 2013 DA - 2013// TI - Gene expressions for signal transduction under acidic conditions JO - Genes (Basel) VL - 4 UR - https://doi.org/10.3390/genes4010065 DO - 10.3390/genes4010065 ID - Fukamachi2013 ER - TY - JOUR AU - Moellering, R. E. AU - Black, K. C. AU - Krishnamurty, C. AU - Baggett, B. K. AU - Stafford, P. AU - Rain, M. PY - 2008 DA - 2008// TI - Acid treatment of melanoma cells selects for invasive phenotypes JO - Clin Exp Metastasis VL - 25 UR - https://doi.org/10.1007/s10585-008-9145-7 DO - 10.1007/s10585-008-9145-7 ID - Moellering2008 ER - TY - JOUR AU - Rofstad, E. K. AU - Mathiesen, B. AU - Kindem, K. AU - Galappathi, K. PY - 2006 DA - 2006// TI - Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-0983 DO - 10.1158/0008-5472.CAN-06-0983 ID - Rofstad2006 ER - TY - JOUR AU - Raposo, G. AU - Nijman, H. W. AU - Stoorvogel, W. AU - Liejendekker, R. AU - Harding, C. V. AU - Melief, C. J. PY - 1996 DA - 1996// TI - B lymphocytes secrete antigen-presenting vesicles JO - J Exp Med VL - 183 UR - https://doi.org/10.1084/jem.183.3.1161 DO - 10.1084/jem.183.3.1161 ID - Raposo1996 ER - TY - JOUR AU - Parolini, I. AU - Federici, C. AU - Raggi, C. AU - Lugini, L. AU - Palleschi, S. AU - De Milito, A. PY - 2009 DA - 2009// TI - Microenvironmental pH is a key factor for exosome traffic in tumor cells JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M109.041152 DO - 10.1074/jbc.M109.041152 ID - Parolini2009 ER - TY - JOUR AU - Ekström, E. l. i. n. J. AU - Bergenfelz, C. a. r. o. l. i. n. e. AU - von Bülow, V. e. r. e. n. a. AU - Serifler, F. i. l. i. z. AU - Carlemalm, E. r. i. c. AU - Jönsson, G. ö. r. a. n. AU - Andersson, T. o. m. m. y. AU - Leandersson, K. a. r. i. n. PY - 2014 DA - 2014// TI - WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells JO - Molecular Cancer VL - 13 UR - https://doi.org/10.1186/1476-4598-13-88 DO - 10.1186/1476-4598-13-88 ID - Ekström2014 ER - TY - JOUR AU - Valenti, R. AU - Huber, V. AU - Filipazzi, P. AU - Pilla, L. AU - Sovena, G. AU - Villa, A. PY - 2006 DA - 2006// TI - Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-1819 DO - 10.1158/0008-5472.CAN-06-1819 ID - Valenti2006 ER - TY - JOUR AU - Peinado, H. AU - Aleckovic, M. AU - Lavotshkin, S. AU - Matei, I. AU - Costa-Silva, B. AU - Moreno-Bueno, G. PY - 2012 DA - 2012// TI - Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET JO - Nat Med VL - 18 UR - https://doi.org/10.1038/nm.2753 DO - 10.1038/nm.2753 ID - Peinado2012 ER - TY - JOUR AU - Hood, J. L. AU - Pan, H. AU - Lanza, G. M. AU - Wickline, S. A. PY - 2009 DA - 2009// TI - Consortium for translational research in advanced imaging and nanomedicine (C-TRAIN). Paracrine induction of endothelium by tumor exosomes JO - Lab Investig VL - 89 UR - https://doi.org/10.1038/labinvest.2009.94 DO - 10.1038/labinvest.2009.94 ID - Hood2009 ER - TY - JOUR AU - Hood, J. L. AU - San, R. S. AU - Wickline, S. A. PY - 2011 DA - 2011// TI - Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis JO - Cancer Res VL - 71 UR - https://doi.org/10.1158/0008-5472.CAN-10-4455 DO - 10.1158/0008-5472.CAN-10-4455 ID - Hood2011 ER - TY - JOUR AU - Peppicelli, S. AU - Bianchini, F. AU - Torre, E. AU - Calorini, L. PY - 2014 DA - 2014// TI - Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells JO - Clin Exp Metastasis. VL - 31 UR - https://doi.org/10.1007/s10585-014-9637-6 DO - 10.1007/s10585-014-9637-6 ID - Peppicelli2014 ER - TY - JOUR AU - Colombo, M. AU - Raposo, G. AU - Thery, C. PY - 2014 DA - 2014// TI - Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles JO - Annu Rev Cell Dev Biol VL - 30 UR - https://doi.org/10.1146/annurev-cellbio-101512-122326 DO - 10.1146/annurev-cellbio-101512-122326 ID - Colombo2014 ER - TY - JOUR AU - Kowal, J. AU - Arras, G. AU - Colombo, M. AU - Jouve, M. AU - Morath, J. P. AU - Primdal-Bengtson, B. PY - 2016 DA - 2016// TI - Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes JO - Proc Natl Acad Sci U S A VL - 113 UR - https://doi.org/10.1073/pnas.1521230113 DO - 10.1073/pnas.1521230113 ID - Kowal2016 ER - TY - JOUR AU - Willms, E. AU - Johansson, H. J. AU - Mager, I. AU - Lee, Y. AU - Blomberg, K. E. AU - Sadik, M. PY - 2016 DA - 2016// TI - Cells release subpopulations of exosomes with distinct molecular and biological properties JO - Sci Rep VL - 6 UR - https://doi.org/10.1038/srep22519 DO - 10.1038/srep22519 ID - Willms2016 ER - TY - JOUR AU - Lai, C. P. AU - Kim, E. Y. AU - Badr, C. E. AU - Weissleder, R. AU - Mempel, T. R. AU - Tannous, B. A. PY - 2015 DA - 2015// TI - Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters JO - Nat Commun VL - 6 UR - https://doi.org/10.1038/ncomms8029 DO - 10.1038/ncomms8029 ID - Lai2015 ER - TY - JOUR AU - Coscia, C. AU - Parolini, I. AU - Sanchez, M. AU - Biffoni, M. AU - Boussadia, Z. AU - Zanetti, C. PY - 2016 DA - 2016// TI - Generation, quantification, and tracing of metabolically labeled fluorescent exosomes JO - Methods Mol Biol VL - 1448 UR - https://doi.org/10.1007/978-1-4939-3753-0_16 DO - 10.1007/978-1-4939-3753-0_16 ID - Coscia2016 ER - TY - JOUR AU - Helmlinger, G. AU - Yuan, F. AU - Dellian, M. AU - Jain, R. K. PY - 1997 DA - 1997// TI - Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation JO - Nat Med VL - 3 UR - https://doi.org/10.1038/nm0297-177 DO - 10.1038/nm0297-177 ID - Helmlinger1997 ER - TY - JOUR AU - WARBURG, O. PY - 1956 DA - 1956// TI - On the origin of cancer cells JO - Science VL - 123 UR - https://doi.org/10.1126/science.123.3191.309 DO - 10.1126/science.123.3191.309 ID - WARBURG1956 ER - TY - JOUR AU - Hess, A. R. AU - Postovit, L. M. AU - Margaryan, N. V. AU - Seftor, E. A. AU - Schneider, G. B. AU - Seftor, R. E. PY - 2005 DA - 2005// TI - Focal adhesion kinase promotes the aggressive melanoma phenotype JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-05-2172 DO - 10.1158/0008-5472.CAN-05-2172 ID - Hess2005 ER - TY - JOUR AU - Jiang, C. C. AU - Chen, L. H. AU - Gillespie, S. AU - Wang, Y. F. AU - Kiejda, K. A. AU - Zhang, X. D. PY - 2007 DA - 2007// TI - Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-2047 DO - 10.1158/0008-5472.CAN-07-2047 ID - Jiang2007 ER - TY - JOUR AU - Knutson, J. R. AU - Iida, J. AU - Fields, G. B. AU - McCarthy, J. B. PY - 1996 DA - 1996// TI - CD44/chondroitin sulfate proteoglycan and alpha 2 beta 1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes JO - Mol Biol Cell VL - 7 UR - https://doi.org/10.1091/mbc.7.3.383 DO - 10.1091/mbc.7.3.383 ID - Knutson1996 ER - TY - JOUR AU - Mizuno, H. AU - Kitada, K. AU - Nakai, K. AU - Sarai, A. PY - 2009 DA - 2009// TI - PrognoScan: a new database for meta-analysis of the prognostic value of genes JO - BMC Med Genet VL - 2 ID - Mizuno2009 ER - TY - JOUR AU - Kobayashi, T. AU - Stang, E. AU - Fang, K. S. AU - de Moerloose, P. AU - Parton, R. G. AU - Gruenberg, J. PY - 1998 DA - 1998// TI - A lipid associated with the antiphospholipid syndrome regulates endosome structure and function JO - Nature VL - 392 UR - https://doi.org/10.1038/32440 DO - 10.1038/32440 ID - Kobayashi1998 ER - TY - JOUR AU - Groot Kormelink, T. AU - Arkesteijn, G. J. AU - Nauwelaers, F. A. AU - van den Engh, G. AU - Nolte-'t Hoen, E. N. AU - Wauben, M. H. PY - 2016 DA - 2016// TI - Prerequisites for the analysis and sorting of extracellular vesicle subpopulations by high-resolution flow cytometry JO - Cytometry A VL - 89 UR - https://doi.org/10.1002/cyto.a.22644 DO - 10.1002/cyto.a.22644 ID - Groot Kormelink2016 ER - TY - JOUR AU - Graham, J. M. PY - 2002 DA - 2002// TI - Purification of lipid rafts from cultured cells JO - ScientificWorldJournal VL - 2 UR - https://doi.org/10.1100/tsw.2002.846 DO - 10.1100/tsw.2002.846 ID - Graham2002 ER - TY - JOUR AU - Yam, X. Y. AU - Birago, C. AU - Fratini, F. AU - Di Girolamo, F. AU - Raggi, C. AU - Sargiacomo, M. PY - 2013 DA - 2013// TI - Proteomic analysis of detergent-resistant membrane microdomains in trophozoite blood stage of the human malaria parasite plasmodium falciparum JO - Mol Cell Proteomics VL - 12 UR - https://doi.org/10.1074/mcp.M113.029272 DO - 10.1074/mcp.M113.029272 ID - Yam2013 ER - TY - JOUR AU - Ishihama, Y. AU - Oda, Y. AU - Tabata, T. AU - Sato, T. AU - Nagasu, T. AU - Rappsilber, J. PY - 2005 DA - 2005// TI - Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein JO - Mol Cell Proteomics VL - 4 UR - https://doi.org/10.1074/mcp.M500061-MCP200 DO - 10.1074/mcp.M500061-MCP200 ID - Ishihama2005 ER - TY - STD TI - The DAVID Knowledgebase. https://david.ncifcrf.gov/. Accessed 5 Feb 2017. UR - https://david.ncifcrf.gov ID - ref30 ER - TY - JOUR AU - Albini, A. AU - Iwamoto, Y. AU - Kleinman, H. K. AU - Martin, G. R. AU - Aaronson, S. A. AU - Kozlowski, J. M. PY - 1987 DA - 1987// TI - A rapid in vitro assay for quantitating the invasive potential of tumor cells JO - Cancer Res VL - 47 ID - Albini1987 ER - TY - JOUR AU - Niu, J. AU - Dorahy, D. J. AU - Gu, X. AU - Scott, R. J. AU - Draganic, B. AU - Ahmed, N. PY - 2002 DA - 2002// TI - Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit JO - Int J Cancer VL - 99 UR - https://doi.org/10.1002/ijc.10397 DO - 10.1002/ijc.10397 ID - Niu2002 ER - TY - STD TI - The Prognoscan database: A new database for meta-analysis of the prognostic value of genes. http://www.prognoscan.org/. Accessed 26 Oct 2017. UR - http://www.prognoscan.org/ ID - ref33 ER - TY - STD TI - The Gene Expression Omnibus functional genomics data repository. https://www.ncbi.nlm.nih.gov/geo. Accessed 22 Oct 2017. UR - https://www.ncbi.nlm.nih.gov/geo ID - ref34 ER - TY - JOUR AU - Pospichalova, V. AU - Svoboda, J. AU - Dave, Z. AU - Kotrbova, A. AU - Kaiser, K. AU - Klemova, D. PY - 2015 DA - 2015// TI - Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer JO - J Extracell Vesicles VL - 4 UR - https://doi.org/10.3402/jev.v4.25530 DO - 10.3402/jev.v4.25530 ID - Pospichalova2015 ER - TY - JOUR AU - Dutta, S. AU - Reamtong, O. AU - Panvongsa, W. AU - Kitdumrongthum, S. AU - Janpipatkul, K. AU - Sangvanich, P. PY - 2015 DA - 2015// TI - Proteomics profiling of cholangiocarcinoma exosomes: a potential role of oncogenic protein transferring in cancer progression JO - Biochim Biophys Acta VL - 1852 UR - https://doi.org/10.1016/j.bbadis.2015.06.024 DO - 10.1016/j.bbadis.2015.06.024 ID - Dutta2015 ER - TY - JOUR AU - Lotvall, J. AU - Hill, A. F. AU - Hochberg, F. AU - Buzas, E. I. AU - Di Vizio, D. AU - Gardiner, C. PY - 2014 DA - 2014// TI - Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles JO - J Extracell Vesicles. VL - 3 UR - https://doi.org/10.3402/jev.v3.26913 DO - 10.3402/jev.v3.26913 ID - Lotvall2014 ER - TY - JOUR AU - Vukovic, V. AU - Tannock, I. F. PY - 1997 DA - 1997// TI - Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan JO - Br J Cancer VL - 75 UR - https://doi.org/10.1038/bjc.1997.201 DO - 10.1038/bjc.1997.201 ID - Vukovic1997 ER - TY - JOUR AU - Raghunand, N. AU - Gillies, R. J. PY - 2000 DA - 2000// TI - pH and drug resistance in tumors JO - Drug Resist Updat VL - 3 UR - https://doi.org/10.1054/drup.2000.0119 DO - 10.1054/drup.2000.0119 ID - Raghunand2000 ER - TY - JOUR AU - Hanahan, D. AU - Weinberg, R. A. PY - 2011 DA - 2011// TI - Hallmarks of cancer: the next generation JO - Cell VL - 144 UR - https://doi.org/10.1016/j.cell.2011.02.013 DO - 10.1016/j.cell.2011.02.013 ID - Hanahan2011 ER - TY - STD TI - The Exocarta database. http://exocarta.org/exosome_markers. Accessed 12 Feb 2017. UR - http://exocarta.org/exosome_markers ID - ref41 ER - TY - JOUR AU - Dror, S. AU - Sander, L. AU - Schwartz, H. AU - Sheinboim, D. AU - Barzilai, A. AU - Dishon, Y. PY - 2016 DA - 2016// TI - Melanoma miRNA trafficking controls tumour primary niche formation JO - Nat Cell Biol VL - 18 UR - https://doi.org/10.1038/ncb3399 DO - 10.1038/ncb3399 ID - Dror2016 ER - TY - STD TI - The Gene Ontology database. http://www.geneontology.org. Accessed 3 Mar 2017. UR - http://www.geneontology.org ID - ref43 ER - TY - JOUR AU - Estrella, V. AU - Chen, T. AU - Lloyd, M. AU - Wojtkowiak, J. AU - Cornnell, H. H. AU - Ibrahim-Hashim, A. PY - 2013 DA - 2013// TI - Acidity generated by the tumor microenvironment drives local invasion JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-2796 DO - 10.1158/0008-5472.CAN-12-2796 ID - Estrella2013 ER - TY - JOUR AU - Robey, I. F. AU - Baggett, B. K. AU - Kirkpatrick, N. D. AU - Roe, D. J. AU - Dosescu, J. AU - Sloane, B. F. PY - 2009 DA - 2009// TI - Bicarbonate increases tumor pH and inhibits spontaneous metastases JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-07-5575 DO - 10.1158/0008-5472.CAN-07-5575 ID - Robey2009 ER - TY - JOUR AU - Fiaschi, T. AU - Giannoni, E. AU - Taddei, M. L. AU - Cirri, P. AU - Marini, A. AU - Pintus, G. PY - 2013 DA - 2013// TI - Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells JO - Cell Cycle VL - 12 UR - https://doi.org/10.4161/cc.24902 DO - 10.4161/cc.24902 ID - Fiaschi2013 ER - TY - JOUR AU - Lardner, A. PY - 2001 DA - 2001// TI - The effects of extracellular pH on immune function JO - J Leukoc Biol VL - 69 ID - Lardner2001 ER - TY - JOUR AU - Muhsin-Sharafaldine, M. R. AU - Saunderson, S. C. AU - Dunn, A. C. AU - Faed, J. M. AU - Kleffmann, T. AU - McLellan, A. D. PY - 2016 DA - 2016// TI - Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles JO - Oncotarget VL - 7 UR - https://doi.org/10.18632/oncotarget.10783 DO - 10.18632/oncotarget.10783 ID - Muhsin-Sharafaldine2016 ER - TY - JOUR AU - Logozzi, M. AU - De Milito, A. AU - Lugini, L. AU - Borghi, M. AU - Calabro, L. AU - Spada, M. PY - 2009 DA - 2009// TI - High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0005219 DO - 10.1371/journal.pone.0005219 ID - Logozzi2009 ER - TY - JOUR AU - Alegre, E. AU - Sanmamed, M. F. AU - Rodriguez, C. AU - Carranza, O. AU - Martin-Algarra, S. AU - Gonzalez, A. PY - 2014 DA - 2014// TI - Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma JO - Arch Pathol Lab Med VL - 138 UR - https://doi.org/10.5858/arpa.2013-0134-OA DO - 10.5858/arpa.2013-0134-OA ID - Alegre2014 ER - TY - JOUR AU - Lazar, I. AU - Clement, E. AU - Ducoux-Petit, M. AU - Denat, L. AU - Soldan, V. AU - Dauvillier, S. PY - 2015 DA - 2015// TI - Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines JO - Pigment Cell Melanoma Res VL - 28 UR - https://doi.org/10.1111/pcmr.12380 DO - 10.1111/pcmr.12380 ID - Lazar2015 ER - TY - JOUR AU - Huang, S. K. AU - Darfler, M. M. AU - Nicholl, M. B. AU - You, J. AU - Bemis, K. G. AU - Tegeler, T. J. PY - 2009 DA - 2009// TI - LC/MS-based quantitative proteomic analysis of paraffin-embedded archival melanomas reveals potential proteomic biomarkers associated with metastasis JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0004430 DO - 10.1371/journal.pone.0004430 ID - Huang2009 ER - TY - JOUR AU - Al-Nedawi, K. AU - Meehan, B. AU - Kerbel, R. S. AU - Allison, A. C. AU - Rak, J. PY - 2009 DA - 2009// TI - Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0804543106 DO - 10.1073/pnas.0804543106 ID - Al-Nedawi2009 ER - TY - JOUR AU - Hong, B. o. k. AU - Cho, J. i. -. H. o. o. n. AU - Kim, H. y. u. n. j. u. n. g. AU - Choi, E. u. n. -. J. e. o. n. g. AU - Rho, S. a. n. g. c. h. u. l. AU - Kim, J. o. n. g. m. i. n. AU - Kim, J. i. AU - Choi, D. o. n. g. -. S. i. c. AU - Kim, Y. o. o. n. -. K. e. u. n. AU - Hwang, D. a. e. h. e. e. AU - Gho, Y. o. n. g. PY - 2009 DA - 2009// TI - Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells JO - BMC Genomics VL - 10 UR - https://doi.org/10.1186/1471-2164-10-556 DO - 10.1186/1471-2164-10-556 ID - Hong2009 ER - TY - JOUR AU - Skog, J. AU - Wurdinger, T. AU - van Rijn, S. AU - Meijer, D. H. AU - Gainche, L. AU - Sena-Esteves, M. PY - 2008 DA - 2008// TI - Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers JO - Nat Cell Biol VL - 10 UR - https://doi.org/10.1038/ncb1800 DO - 10.1038/ncb1800 ID - Skog2008 ER - TY - JOUR AU - Webber, J. AU - Steadman, R. AU - Mason, M. D. AU - Tabi, Z. AU - Clayton, A. PY - 2010 DA - 2010// TI - Cancer exosomes trigger fibroblast to myofibroblast differentiation JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-10-1722 DO - 10.1158/0008-5472.CAN-10-1722 ID - Webber2010 ER -