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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway

Fig. 4

miR-423-5p regulates the small GTPase Rho/Rac signaling pathway through AFAP1-AS1. a. Many molecules in the Rho/Rac signaling pathway, including RAB10, RAB11A, RAC2, PFN1, RHOA, RAC1, RHOC, LASP1 and RAB11B, were regulated at the mRNA level in 5-8F and HNE2 cells by AFAP1-AS1 overexpression or knockdown. b. Many molecules in the Rho/Rac signaling pathway, including RAB10, RAB11A, RAC2, PFN1, RHOA, RAC1, RHOC, LASP1 and RAB11B, were regulated at the mRNA level in 5-8F and HNE2 cells by overexpression or knockdown of miR-423-5p. c. Expression of Rho/Rac proteins, including RAB10, RAB11A, RAC2, PFN1, RHOA, RAC1, RHOC, LASP1 and RAB11B, was examined at the protein level in 5-8F and HNE2 cells after overexpression or knockdown of miR-423-5p.*, p < 0.05; **, p < 0.01; ***, p < 0.001

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