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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression

Fig. 7

ATF3 expression was positively correlated with CYR61 expression in primary HCC tissues. The mRNA expression of ATF3 and CYR61 in 30 pairs of HCC and noncancerous liver tissues was detected by qRT-PCR (a), which was also used to analyze 50 pairs of cancerous and noncancerous liver tissues from the TCGA (b). c The correlation between ATF3 and CYR61 mRNA levels in 30 paired cancerous/noncancerous liver tissues from primary HCC patients and 373 paired samples from the TCGA cohort. The Pearson correlation coefficients (r) and p value are indicated. d Representative images of ATF3 and CYR61 protein staining by IHC in cancerous /noncancerous liver tissues (scale bar, 100 μm.). e The positive correlation between ATF3 and CYR61 protein levels in 236 human primary HCC tissues is presented. r, Pearson correlation coefficient; p, p value. f Kaplan–Meier analysis of overall survival in 222 HCC patients, as stratified by ATF3 expression. The log-rank test was used to determine statistical significance. *P < 0.05 and **P < 0.01

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