Table 6 Metastatic genes correlated with miR-200b expression gene in DPBC and TNBC TCGA patient
From: Aberrant miRNAs expressed in HER-2 negative breast cancers patient
Metastatic site | Gene | DPBC | TNBC | ||||
|---|---|---|---|---|---|---|---|
Pearson R | 95% confidence interval | P value | Pearson R | 95% confidence interval | P value | ||
Brain metastasis marker | BRCA2 | −0,02537 | −0,1161 to 0,06580 | 0,5745 | 0,08805 | −0,07530 to 0,2468 | 0,2760 |
PARP1 | 0,02377 | −0,06739 to 0,1145 | 0,5988 | 0,1341 | −0,02884 to 0,2900 | 0,0963 | |
Lung metastasis marker | TFF1 | 0,2018 | 0,1129 to 0,2876 | 0,0001 | −0,1995 | −0,3504 to −0,03850 | 0,0128 |
RARA | 0,02082 | −0,07033 to 0,1116 | 0,6450 | −0,3054 | −0,4456 to −0,1506 | 0,0001 | |
Liver metastasis | CDH2 | −0,1995 | −0,2854 to −0,1105 | 0,0001 | −0,07199 | −0,2316 to 0,09134 | 0,3734 |
ERCC2 | 0,05412 | −0,03709 to 0,1444 | 0,2308 | 0,003711 | −0,1587 to 0,1659 | 0,9634 | |
Bone metastasis | MTA1 | 0,2114 | 0,1227 to 0,2967 | 0,0001 | 0,1552 | −0,007210 to 0,3097 | 0,0538 |
KPNA2 | −0,006807 | −0,09777 to 0,08427 | 0,8803 | 0,1641 | 0,001867 to 0,3179 | 0,0413 | |
BMP2 | −0,2626 | −0,3454 to −0,1758 | 0,0001 | −0,2030 | −0,3536 to −0,04209 | 0,0113 | |
BMP4 | −0,1170 | −0,2058 to − 0,02625 | 0,0094 | − 0,2244 | − 0,3730 to − 0,06443 | 0,0050 | |
VIM | -0,3409 | -0,4189 to − 0,2579 | 0,0001 | -0,2438 | -0,3906 to −0,08490 | 0,0022 | |
CD44 | -0,09716 | -0,1865 to −0,006196 | 0,0312 | 0,02089 | -0,1419 to 0,1825 | 0,7964 | |
PTX3 | -0,2637 | -0,3464 to −0,1770 | 0,0001 | -0,08625 | -0,2451 to 0,07709 | 0,2859 | |
TNFSF11 | -0,1752 | -0,2620 to −0,08554 | 0,0001 | -0,2297 | -0,3779 to −0,07002 | 0,0040 | |
CTNNB1 | -0,1828 | -0,2694 to −0,09335 | 0,0001 | -0,1193 | -0,2762 to 0,04384 | 0,1394 | |
NFKB1 | -0,1346 | -0,2229 to −0,04411 | 0,0028 | -0,1166 | -0,2737 to 0,04652 | 0,1484 | |
VDR | -0,1421 | -0,2301 to −0,05171 | 0,0016 | -0,1324 | -0,2885 to 0,03051 | 0,1005 | |