Fig. 6

The effect of DANCR on tumorigenicity of bladder cancer cells. a: Tumors collected from mice were exhibited. b: Tumor volume curve of DANCR or NC treatment groups were measured and analyzed. c: Tumor free mouse proportion of DANCR or NC treatment groups were measured and analyzed. d: Tumor weight of DANCR or NC treatment groups were measured and analyzed. Knockdown of DANCR inhibited the tumorigenicity of bladder cancer cells in vivo. e and f: Knockdown of DANCR increased miR-149 expression, decreased MSI2 expression and inhibited EMT of bladder cancer cells in vivo. g: Knockdown of DANCR decreased MSI2 and Ki67 expression of bladder cancer cells in vivo. h: Knockdown of DANCR decreased MSI2 expression of bladder cancer cells. Moreover, DANCR and MSI2 were co-localized in bladder cancer cells in vivo. Data are shown as mean ± SD. *p < 0.05; **p < 0.01