Fig. 5
From: AFF3 upregulation mediates tamoxifen resistance in breast cancers
AFF3 overexpression activates the ER signaling pathway and increases the expression of ER-regulated genes. a Luciferase assay indicating the trans-activity of ER in MCF-7 and T47D cells with AFF3 overexpression or knockdown. *P < 0.05. Bars represent the mean ± SD of three independent experiments. b Real-time PCR analysis of mRNA levels of the ER-related genes in MCF-7 and T47D cells with AFF3 overexpression or knockdown