Fig. 2
From: Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner
LNT treatments reduce tumor vessel function in an inversed U-shaped dose-response manner. LAP0297 tumor bearing mice were treated with different doses of LNT for 10 days as described in Fig. 1. Tumor tissues were sectioned and stained with an anti-CD31 antibody. a Representative figures showing tumor vessel density and vascular function in NS control and LNT (1 and 5 mg/kg) groups. b The mean fluorescence intensity (MFI) of CD31 (Red) and Hoechst 33342 (Blue) stained areas was quantified. CD31 is an endothelial cell marker. The intensity of Hoechst 33342 perfusion reflects the function of tumor vessels. ns: no significantly different, * p < 0.05, *** p < 0.001